Police said it is believed a car and a truck collided head-on at the intersection of Goulburn Valley Hwy and Moira Drive about 12.55pm.
The driver and sole occupant of the car died at the scene and is yet to be formally identified.
The truck driver sustained serious injuries and was treated by paramedics.
An Ambulance Victoria spokesperson said two people were taken to Goulburn Valley health by ambulance.
A man in his 20s was taken to hospital in a stable condition with upper body injuries, while a man in his 60s was taken to hospital in a stable condition for observation, the spokesperson said.
The highway was closed, with traffic detoured around the scene via River Rd, Central Kialla Rd and Murchison-Violet Town Rd, while police investigated the crash.
The circumstances surrounding the collision are yet to be determined and an investigation is ongoing.
Anyone who witnessed the collision or who has dashcam footage is urged to contact Crime Stoppers on 1800 333 000 or submit a report online at www.crimestoppersvic.com.au
EARLIER: Emergency services are on the scene of an incident on the Goulburn Valley Highway in Kialla West near the Kialla Uniting Church.
Two people have been taken to Goulburn Valley Health following the incident at about 12.55pm.
Their condition is unknown.
The incident is believed to involve heavy vehicles, but the News was unable to confirm the nature of the incident.
The road has been closed in both directions, with detours in place at River Rd in the north.
It’s advised to avoid the area.
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