Mark Axelowitz, an actor who plays a Manhattan prosecutor in the new Robert De Niro film The Alto Knights, was one of more than a dozen candidates who raised a hand when the judge asked if anyone felt they could not be impartial.
"I don't like the guy, he is a really bad guy," Axelowitz told a reporter after being dismissed from consideration.
Another dismissed prospective juror disqualified herself because she had previously been sexually assaulted.
Yet another said, "I don't see how anyone can be impartial."
Weinstein is being tried again after New York's highest court, the Court of Appeals, last year overturned his 2020 conviction and 23-year prison sentence and ordered a new trial, finding that improper rulings and prejudicial testimony tainted the original one.
That ruling gave Weinstein a second chance to fight the charges, with his new trial playing out in a different atmosphere than his first trial, which was held in the middle of a global reckoning over sexual misconduct.
Weinstein, 73, who has pleaded not guilty and denies that he raped or sexually assaulted anyone, is older and more frail, in and out of the hospital regularly for a variety of health problems.
He is now far removed from when he was among the most powerful men in the movie business.
Even if he is acquitted, he will not walk free.
Weinstein is also appealing a 2022 rape conviction in Los Angeles.
His 16-year prison sentence in that case still stands although his lawyers said he needs to be re-sentenced because the since-vacated New York conviction factored into how his punishment was calculated.
Weinstein is being retried on two charges from his original trial.
He is accused of raping an aspiring actor in a Manhattan hotel room in 2013 and performing a criminal sex act by forcing oral sex on a production assistant in 2006.
He is also charged with one count of criminal sex act based on an allegation from a woman who was not a part of the original trial.
That woman, who has asked that she not be named publicly, alleges that Weinstein forced oral sex on her at a Manhattan hotel.
Speaking outside the courthouse on Tuesday, that accuser's lawyer Lindsay Goldbrum said one thing would become "crystal clear" from her client's upcoming testimony at the trial: "This was not consensual. This was sexual assault with force."
"I am confident that there will be justice in this case," Goldbrum told reporters, adding that her client was resolved to testify.
"It is important for women everywhere and for people who are victims of sexual assault everywhere that others pave the way and show their dedication in this fight against sexual assault."
Judge Curtis Farber has set aside at least four days for jury selection and expects opening statements and the start of testimony next week.
The judge, prosecution and defence will work to whittle a massive pool of potential jurors down to the 18 people - 12 jurors and six alternates - needed for the trial by asking questions and seeking to eliminate anyone they feel cannot judge the case fairly.
